Lipstick Jungle weaves the stories of Nico O'Neilly, Wendy Healy, and Victory Ford, numbers 8, 12, and 17 on The New York Post's list of "New York's 50 Most Powerful Women." But this is 21st Century New York, and to get ahead and stay ahead, these women will do anything, including jeopardizing their personal and professional relationships. Take for example Nico, editor-in-chief of Bonfire magazine, who betrays her boss to rise to the top of the entire magazine division at media mega-giant Splatch-Verner. As president of Paradour Pictures, Wendy may be poised to win an Oscar for her 10-year labor-of-love, Ragged Pilgrims, but her marriage is in shambles and her children care more about a $50,000 pony than their mother. And for single, 43-year-old fashion designer Victory, pleasing tough critics may be more important than ever finding the real relationship she's convinced herself she doesn't need.