Milad is five years old and excited for his school trip to a theme park on the outskirts of Jerusalem, but tragedy awaits: his bus is involved in a horrific accident. His father, Abed, rushes to the chaotic site, only to find Milad has already been taken away. Abed sets off on a journey to learn Milad's fate, navigating a maze of physical, emotional, and bureaucratic obstacles he must face as a Palestinian.

Interwoven with Abed's odyssey are the stories of Jewish and Palestinian characters whose lives and pasts unexpectedly converge: a kindergarten teacher and a mechanic who rescue children from the burning bus; an Israeli army commander and a Palestinian official who confront the aftermath at the scene of the crash; a settler paramedic; ultra-Orthodox emergency service workers; and two mothers who each hope to claim one severely injured boy.

A Day in the Life of Abed Salama is a deeply immersive, stunningly detailed portrait of life in Israel and Palestine, and an illumination of the reality of one of the most contested places on earth.